The visiting team must win the game in Mumbai in order to have a chance to square the series at Chennai.
Qarabag need the victory in the match against Fiorentina this Thursday if they want to qualify for the knockout stage of the competition.
The four teams in Group L of 2016/17 Europa League are separated by 1 point, which makes the matchday 6 fixture extremely crucial for all involved.
Both Maccabi Tel-Aviv and Dundalk are locked on 4 points and a win for either sides will send them through if AZ loses.
UEFA group stage debutant Zorya will be hoping to bow out high when they welcome Manchester United to Stadium Chornomorets.
Gloucester host La Rochelle at Kingsholm in the Challenge Cup.
Southampton and Hapoel Beer Sheva are both battling to finish second in the group. A win for either side would take them through to the round of 32.