Ajax have a 100 per cent record after two games so Chelsea will need to be at the top of their game.
The Russian outfit have done well at this stage of the competition in recent seasons, winning seven of their last 10 matches.
This should be a relatively routine win for Federer.
Huddersfield Town come into this encounter against Middlesbrough looking to extend their unbeaten run of four games.
Liverpool return to European action following a controversy-laden 1-1 draw with bitter rivals Manchester United.
nter Milan welcome Borussia Dortmund to the San Siro on Wednesday night with both sides looking for a big result in the Champions League.
Wednesday's fixture is arguably one of the biggest in Slavia's history, having never previously squared off against Barca or Real Madrid in a competitive encounter.
This really has all the makings of a thriller.
New York City FC begin their playoff run this Wednesday night against Toronto FC at Citi Field.
How will the Celtics adjust with the loss of Kyrie Irving?